Serum Amyloid A (SAA) proteins are a family of apolipoproteins that are highly conserved, and is produced by activated monocytes and macrophages, and are secreted from certain extra-hepatic sites in chronic inflammatory diseases. After secretion into the circulation, it associates with high-density lipoprotein (HDL) particles. These proteins have several roles, including the transport of cholesterol to the liver for secretion into the bile, the recruitment of immune cells to inflammatory sites, and the induction of enzymes that degrade the extracellular matrix. SAA is a sensitive marker for infection, inflammation, injury, or stress. Circulatory SAA levels rise dramatically during acute phase reactions in response to a trauma or infection. Anti-Human SAA serum is used for the diagnosis of inflammation in the patient.